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The conversion of dehydroisoandrosterone sulfate (DS) to 16α-hydroxydehydroisoandrosterone-3-sulfate (16αHODS) was studied in patients with prostatic cancer, before and after one month of treatment with either diethylstilbestrol (DES) or 6α-methyl-17-acetoxyprogesterone (Provera®). A mixture of 3H-16α-HODS and 14CDS was administered intravenously in each experiment and the 3H/14C ratio in 16α-HODS isolated from pooled urine, collected for 3 days following the injection, was measured. The conversion of blood-borne DS to blood-borne 16α-HODS was found to be high (11 to 46%) before treatment and to about double as a result of the administration of DES. No changes occurred during treatment with medroxyprogesterone acetate. It is concluded from these results that 16α-hydroxylation is a quantitatively important path of metabolism of DS in men and that the enzymatic activity can be increased by estrogenic compounds.
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Gurpide et al. (1973) studied this question.
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