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Demonstrates rapid quantitative measurement of urinary tetrahydroaldosterone using gas chromatography, highlighting reduced analysis time over double isotope derivative methods.
The monochlorodifluoroacetate of the γ-lactone of 3α,5β-tetrahydroaldosterone is easily prepared, sufficiently stable and can be measured in mμg amounts with an electron capture detector. When isolated from human urine by 3 thin layer chromatograms this substance is sufficiently pure for quantitative analysis by gas chromatography. The results obtained by gas chromatography were comparable to those obtained by a double isotope derivative method, while the time required for analysis was considerably less.
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NICOLIS et al. (1968) studied this question.
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