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A highly enantioselective methodology has been developed to access oxindole-fused spiro dihydrobenzofuran, applicable to a protecting-group-free reactant, with high bond efficiency (1 new C–C and 1 C–O bond) and two contiguous stereocenters. Gram-scale and stereodivergent synthesis without compromising yield and selectivity illustrates the potential practicality of the protocol. Dynamic HRMS titrations were conducted to propose the reaction mechanism.
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Devi et al. (2026) studied this question.
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