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Summary An assay for potency of adenovirus vaccine in guinea pigs based on the antigen extinction principle is described. The potency test values in repeat titrations were reproducible within a maximal 7-fold range. Further need for control with a standard reference vaccine is indicated. Potency values for a number of vaccines of diverse origin are presented. These ranged in potency from 66-fold difference for type 4 to 1667-fold difference for type 7 component. The correlation of animal potency value with efficacy in field trials and the limitations of the test are discussed.
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Binn et al. (1960) studied this question.
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