Key result
Concentrated formalinized polio vaccine matches live virus antigenicity in guinea pigs, while UV light destroys it.
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This preclinical study evaluated the immunogenic potency of live versus inactivated poliomyelitis viruses in guinea-pigs.
The antigenic response of guinea-pigs to live poliomyelitis viruses of all three types has been studied and the loss of antigenicity involved in inactivation by formaldehyde and by ultra-violet light have been determined. We wish to acknowledge the debt we owe to the late Prof. M. van den Ende for his great help and interest in this work, and we are grateful for the assistance received from Dr H. Malherbe and Ruth Harwin in carrying out many of the titrations, and from Dr T. Mead for synthesizing some 1:4-diphenylbutadiene for use as a filter for ultra-violet light. We also have to thank G. S. Turner, T. Norcott, Doreen Deeks and Margaret Pakes for their technical help.
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Hampton et al. (1958) studied Poliomyelitis immunization. Live and inactivated poliomyelitis virus was evaluated on Percentage of protective sera (neutralizing antibody). Concentrated formalinized poliomyelitis vaccine demonstrated comparable antigenicity to live virus in guinea-pigs, whereas inactivation with ultra-violet light or 0.2% formaldehyde destroyed antigenicity.
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