Key result
Bipolar Holter ECG provides a simple, feasible method for cardiac monitoring in small experimental animals.
Why the study?
The use of long-term electrocardiographic Holter monitoring in various small animal species for experimental veterinary practice required summarization of hardware, software, and anesthesia requirements.
Supports bipolar-lead Holter in small-animal models; leaves open validation and clinical translation.
The long-term electrocardiographic recording with retrospective evaluation (Holter system) has been widely used not only in cardiology, but also in other disciplines of internal medicine and in pharmaceutical research. The Holter system can be used in mini-pig, sheep, dog, cat, rabbit, ferret, and rat. In this paper hardware, software, and anesthesia requirements are summarized with respect to the experimental work with various species. As the Holter systems work in bipolar mode, the use of bipolar leads in sagittal and transversal planes has been proved to be the most appropriate because of large amplitude of QRS complex and uncomplicated consequent automatic analysis of the record. In conclusion, Holter electrocardiography represents a simple and applicable method for monitoring the electrical activity of the heart in small animals' experimental studies.
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Sepši et al. (2010) reported a review. Electrocardiographic Holter monitoring was evaluated. Holter electrocardiography using bipolar leads represents a simple and applicable method for monitoring the electrical activity of the heart in small experimental animals.
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