Rare Extrapulmonary Metastases from Thigh Myxoid Liposarcoma: Two Case Reports and Literature Review

This is the authors' abstract. We don't add key points for this paper.

Liposarcoma (LPS) is one of the most common extremity soft tissue sarcoma types arising from adipose tissue. About one-third of patients with primary localized extremity soft tissue sarcomas will develop metastatic disease during follow-up, most frequently in the lungs. Myxoid LPS (MLS) roughly represents 20%-30% of all LPSs. Unfortunately, about 10% of patients with MLS present with metastasis of the tumor in unusual sites, such as the thorax and retroperitoneum.In the present case report, we present two cases with thigh soft tissue sarcomas metastasizing to rare sites; one to the breast and the other to the soft tissue of the neck. Their clinical presentation, radiologic, and histopathologic evaluation, in addition to their management plans, are reported in detail.Extrapulmonary metastasis from MLS represents a diagnostic dilemma. Although multimodality approaches, including surgery, radiotherapy, and chemotherapy, are used for managing MLS, a case-by-case approach is still recommended to achieve the most favorable outcomes.