Predictive Validly of the Toronto IBD Global Endoscopic Reporting (TIGER) Score for Clinical Outcomes and Quality of Life Among Ulcerative Colitis and Crohn’s Disease Patients

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Aims The recently developed TIGER endoscopy score was established to reliably describe disease severity as it can be utilized for both Ulcerative Colitis (UC) and Crohn’s disease (CD) patients. 1 The aim of this study was to assess the TIGER score’s ability to predict outcomes regarding complications and quality of life of both UC and CD patients. Methods A cohort of 78 patients (UC n=40, and CD n=38) followed for 52-week in multiple visit prospective study. Each visit included patient interviews, disease specific quality of life IBD disk questionnaire, blood draws for C-reactive protein (CRP) mg/DL, and fecal calprotectin (FC) μg/g. Baseline total TIGER endoscopy scores were dichotomized as <100 (remission-mild activity) or ≥100 (moderate-severe activity) [ 1 ]. Results At baseline UC patients with TIGER scores ≥100 had significantly higher CRP, FC, and IBD disk. In CD patients, at baseline, compared to patients with TIGER scores <100, patients with TIGER scores ≥100 had significantly higher CRP, FC, and IBD disk. In terms of hospitalizations, at 52-weeks, patients with baseline TIGER scores ≥100 had a significantly increased likelihood of being hospitalized(p<0.02). In terms of side effects, at 52-weeks, compared to patients with baseline TIGER scores <100, UC and CD patients with baseline TIGER scores ≥100 had a significantly increased likelihood of reporting a side effect from both medications and disease complications (p<0.006). Conclusions The TIGER endoscopic score demonstrates significant association with CRP, FC and disease-specific quality of life IBD disk questionnaire in both UC and CD patients. Publication History Article published online: 14 April 2023 © 2023. European Society of Gastrointestinal Endoscopy. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany