Key result
Adipocyte mineralocorticoid receptor overexpression impairs arteriolar contractility via elevated hydrogen peroxide.
Why the study?
Obesity, insulin resistance, and T2DM are associated with increased aldosterone and cardiovascular MR activation contributing to hypertension and CVD, but the role of extrarenal MR signaling in adipose and vascular dysfunction is not fully understood.
Adipocyte MR may contribute to microvascular dysfunction in metabolic disease; leaves open whether selective targeting augments MRA benefits.
No takes yet. Share an insight, caveat, or question.
Jia et al. (2016) conducted an editorial in Obesity and cardiovascular disease. Adipocyte-specific mineralocorticoid receptor (MR) overexpression was evaluated. Adipocyte-specific mineralocorticoid receptor overexpression increases adipose-derived hydrogen peroxide and impairs arteriolar vascular smooth muscle contractility.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: