Key result
Adrenalectomy prevents postprandial rises in cholesterol, phospholipids, and glucose in hypertriglyceridemic rats.
Why the study?
The effects of adrenalectomy on plasma lipid and glucose responses following triglyceride ingestion in hypertriglyceridemic rats were unclear.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for adrenal modulation of postprandial lipids; does not support clinical translation without human data.
Adrenalectomy did not significantly alter plasma cholesterol, triglycerides and phospholipids in fasted naturally hypertriglyceridemic rats. Oral administration of cottonseed oil resulted in elevations in plasma cholesterol and phospholipids within 2 hr. Adrenalectomy negated these elevations. Triglycerides rose to an equal extent in both groups at the same time. A secondary rise in plasma glucose was noted at about 7 hr in the control rats; this rise was also negated by adrenalectomy.
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Lenz et al. (1969) studied Hypertriglyceridemia. Adrenalectomy vs. Control (no adrenalectomy) was evaluated on Plasma cholesterol, triglycerides, phospholipids, and glucose levels. Adrenalectomy negated the elevations in plasma cholesterol and phospholipids seen at 2 hours, and glucose seen at 7 hours, following cottonseed oil ingestion in hypertriglyceridemic rats.
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