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January 1, 1995The Journal of AntibioticsOpen Access

Phosphonothrixin, a Novel Herbicidal Antibiotic Produced by Saccharothrix sp. ST-888. II. Structure Determination.

Takashi Kimura Kazuhiko Nakamura Eisaku Takahashi

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Abstract

Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888. This unique compound possessing a C-P bond and an isoprene unit was determined to be 2-hydroxy-2-hydroxymethyl-3-oxobutyl-phosphonic acid. Unusually rapid proton-deuterium (H-D) exchange of the methyl ketone unit of this antibiotic in D2O solution was observed. Phosphonothrixin can be classified as a new type of natural product herbicide having a C-P bond in the molecule.

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Kimura et al. (1995) studied this question.

synapsesocial.com/papers/6acc3302dea536ba7d803c39 https://doi.org/10.7164/antibiotics.48.1130

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