Key result
BNT162b2 vaccination linked to ~7.9-fold higher risk of myocarditis or pericarditis.
Why the study?
The incidence and risk of myocarditis/pericarditis following COVID-19 vaccination with BNT162b2, CoronaVac, and ChAdOx1 in adolescents and adults in Malaysia were not well described.
Cohort
Yes
Answers are grounded in this paper and cite their sources.
Supports myocarditis surveillance after BNT162b2 in young males; extends prior mRNA vaccine safety data to a Malaysian population.
This study evaluates 21-day risk of myocarditis/pericarditis following COVID-19 vaccination among those aged 12 years and older in Malaysia. We used data from nationwide COVID-19 vaccine registry linked to hospital episode database to identify individuals vaccinated with BNT162b2, CoronaVac, or ChAdOx1 and hospitalised for myocarditis/pericarditis between 1 February 2021 and 28 February 2022. There were 87 myocarditis/pericarditis cases identified within 1-21 days after vaccination. Most cases were reported following BNT16262 vaccination (77.0%) with absolute risk of 0.33 cases/100,000 vaccinated persons or 1.73 per million doses administered. Highest risk was observed following second dose and in younger, male individuals. The risk of myocarditis/pericarditis following CoronaVac and ChAdOx1 were much lower compared to BNT162b2. The findings on higher risk observed among younger following mRNA vaccine were consistent with literature and important for targeted surveillance.
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Rahman et al. (2023) conducted a cohort in Myocarditis and pericarditis. BNT162b2 COVID-19 vaccination vs. Background incidence (2019) was evaluated on First hospital admission for myocarditis/pericarditis within 1 to 21 days of receipt of COVID-19 vaccine (Risk ratio 7.91, 95% CI 4.08 to 15.5). BNT162b2 vaccination was associated with a higher risk of myocarditis or pericarditis compared to the background rate, with an absolute risk of 0.33 cases per 100,000 vaccinated persons.
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