Key result
Clustering CV risk factors correlates with ACVD in elderly patients despite low overall prevalence.
Why the study?
The association between high risk factors and atherosclerotic cardiovascular diseases in elderly subjects was unclear, especially regarding the importance of factor cumulation.
Observational (n=509)
Supports link between risk factor accumulation and ACVD in older adults; leaves open whether modification improves outcomes.
The association between the so‐called “high risk” factors — hypercholesterolemia, hypertension, diabetes — and atherosclerotic cardiovascular diseases (ACVD) was studied in 509 subjects over 60 years of age. The correlation between these factors (especially their cumulation) and the prevalence of clinically evident ACVD was statistically significant. Nevertheless, in comparison to the high prevalence of atherosclerosis in these groups of elderly subjects, the prevalence of cumulation of two or even three of these atherogenic factors was relatively so low that their atherogenic importance appeared questionable. This fact may be of great importance in the strategy for prevention of myocardial infarction and cerebrovascular accidents in these age groups.
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M. Vavřík (1974) conducted an observational in Atherosclerotic cardiovascular diseases (ACVD) (n=509). High risk factors (hypercholesterolemia, hypertension, diabetes) vs. Fewer or absent high risk factors was evaluated on Prevalence of clinically evident ACVD. Cumulation of hypercholesterolemia, hypertension, and diabetes significantly correlated with clinically evident ACVD, but its low frequency questioned its overall atherogenic importance in the elderly.
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