Key result
Left-sided ischemic stroke is linked to ~5-point lower LVEF compared to controls.
Why the study?
Hemispheric ischemic stroke influences cardiac function to varying degrees, but the features of cardiac hemodynamics by stroke lateralization remain incompletely understood.
Does hemispheric lateralization in ischemic stroke differentially associate with left ventricular systolic function impairment?
Observational (n=162)
No
Does hemispheric lateralization in ischemic stroke differentially associate with left ventricular systolic function impairment?
Effect estimate: Hedge's g 0.5
Absolute Event Rate: 55.31% vs 59.91%
p-value: p=0.036
Elderly patients with ischemic stroke, particularly those with left-sided lesions, show echocardiographic signs of left ventricular dilatation and decreased systolic function compared to non-stroke matched controls.
Highlights potential cardio-cerebral interactions in left-sided stroke; leaves open causality and clinical impact pending prospective studies.
Hemispheric ischemic stroke (IS) is widely known to claim to be one of the prevalent factors of disability and mortality worldwide, influencing the cardiac function in different degree as well. Purpose of the work. The aim of the study is a step forward in comprehensive understanding the features of cardiac hemodynamics in right-sided ischemic stroke (RSIS), left-sided ischemic stroke (LSIS) and individuals without clinical evidence or history of IS, referred for ultrasound examination for non-cerebrovascular indications. Materials and methods. The transthoracic echocardiography (TTE) was conducted using phased-array probe with available working range of 1.0 – 5.0 MHz, accounting for left ventricle sonography recommendations and protocols, after assessing the data distribution type the results of TTE of 111 patients with IS and 51 age- and gender groups-matched individuals without clinical evidence or history of ischemic stroke, referred for ultrasound examination for non-cerebrovascular indications, were analysed with suitable parametric and non-parametric methods. Results. The results of the TTE in the elderly (mean age 65.98±13.01 years old) presented the overall decrease in left ventricle systolic function in IS patients, however, more obviously in LSIS. In the current study left ventricle systolic and diastolic volume tended to correlate positively with weak association with National Institutes of Health Stroke Scale (NIHSS) on discharge. Conclusions. The elderly ischemic stroke individuals showed left ventricle dilatation and decreased contracting function as compared to the individuals with no ischemic stroke presentation or history, with being more significant in the left-sided ischemic stroke, that should be interpreted as additional findings rather than a primary determinant or strong evidence of distinct stroke lateralisation affect on the cardiac function. Further researches upon moderate to large samples are needed to study the stroke-heart syndrome in various popupations comprehensively.
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Yefimenko et al. (2026) conducted an observational in Hemispheric ischemic stroke (n=162). Left-sided ischemic stroke vs. No ischemic stroke was evaluated on Left ventricle ejection fraction (%) (Hedge's g 0.5, p=0.036). Patients with left-sided ischemic stroke exhibited a significantly decreased left ventricular ejection fraction (55.31% vs 59.91%, p=0.036) and overall systolic dysfunction compared to individuals without a history of stroke.
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