Recent data on gastro-oesophageal reflux disease management strategies suggest that the indirect costs of reflux disease are high, and that inadequate treatment is associated with significant out-patient costs for patients. Long-term management strategies now focus on discontinuous therapy for some subgroups of patients. On-demand therapy is particularly attractive for patients who have no mucosal disease.
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Nimish B. Vakil (2002) studied this question.
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