Key result
Splenectomy is linked to an absolute ~0.9 mmol/L increase in LDL at 1 year.
Why the study?
The metabolic effects of splenectomy, particularly on lipid metabolism, are not fully understood and previous studies have produced differing and contradictory results.
Cohort (n=38)
Yes
Absolute Event Rate: 6.1% vs 5.23%
p-value: p=0.02
May warrant lipid monitoring post-splenectomy; leaves open cardiovascular risk implications pending prospective data.
Background: Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. Methods: The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study. Results: Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL. Conclusion: We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.
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Güneş et al. (2022) conducted a cohort in Splenectomy (various indications) (n=38). Splenectomy vs. Pre-operative baseline was evaluated on Low-density lipoprotein (LDL) levels (mmol/L) (p=0.02). Splenectomy significantly increased total cholesterol, LDL (from 5.23 to 6.10 mmol/L), and non-HDL levels 1 year post-surgery compared to preoperative baseline values.
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