Key result
Total splenectomy fails to alter plasma lipid levels in mice over 75 days.
Why the study?
The effect of total splenectomy on the lipid profile in Balb/c mice was analyzed to understand its impact on plasma lipid levels.
Neutral lipid effects in this murine model; hypothesis-generating for human splenectomy patients and requires clinical validation.
PURPOSE: To analyze total splenectomy effect on the lipid profile - total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), very-low-density lipoprotein cholesterol (VLDL) and triglycerides levels, in Balb/c mice. METHODS: Thirty Balb/c male mice, one (1) month old and average weight 26.2g ± 4.0 were used in the experiment. They were distributed into three groups of 10 animals each: a control group (non-operated), a simulation group (spleen manipulation) and the splenectomy group. The animals were subjected to blood sampling to measure plasma lipid levels, at three different times: before surgery, days 30 and 75 of the experiment. RESULTS: Increased total cholesterol and LDL were observed in the control group from the start to end of the experiment. The simulation group showed increased rates of VLDL and triglycerides at the 30th and 75th days. Splenectomized animals showed no significant change. CONCLUSION: Total splenectomy did not induce increased plasma lipids levels of in Balb/c mice.
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Demuner et al. (2015) studied this question. Total splenectomy vs. Control (non-operated) and simulation (spleen manipulation) was evaluated on Plasma lipid levels (total cholesterol, LDL, HDL, VLDL, and triglycerides). Total splenectomy did not induce significant changes or increased plasma lipid levels in Balb/c male mice over a 75-day follow-up period.
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