Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary Hepatoma

Case Studies1 March 1966Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary HepatomaWILLIAM BELL, M.D., RAYMOND BAHR, M.D., THOMAS A. WALDMANN, M.D., PAUL P. CARBONE, M.D.WILLIAM BELL, M.D.Search for more papers by this author, RAYMOND BAHR, M.D.Search for more papers by this author, THOMAS A. WALDMANN, M.D.Search for more papers by this author, PAUL P. CARBONE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-658 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1955, Korst and Kratochvil (1) reported a patient with a pulmonary neoplasm and thrombophlebitis migrans in whom a cold-preciptable fibrinogen (cryofibrinogen) was detected. Subsequently, cryofibrinogenemia has been described as a primary (idiopathic) and more frequently as a secondary disorder (2). Primary (2) and secondary (3) cryofibrinogenemia may be associated with cold intolerance, Raynaud's phenomenon, and acrocyanosis. In the secondary disorder, thrombo-embolic occlusive phenomena and hemorrhagic diatheses are common.The present report concerns a patient with a primary hepatoma and markedly elevated plasma levels of fibrinogen and cryofibrinogen. These findings were not associated with any thrombotic or bleeding disorders or...References1. KORSTKRATOCHVIL DRDH: Cryofibrinogen in a case of lung neoplasm associated with thrombophlebitis migrans. Blood 10: 945, 1955. CrossrefMedlineGoogle Scholar2. RITZMANNLEVIN SEWC: Cryopathies: a review. Classification; diagnostic and therapeutic considerations. Arch. Intern. Med. (Chicago) 107: 754, 1961. CrossrefMedlineGoogle Scholar3. LEVINLONGGREGORYRITZMANN WCPARSE: Secondary cryofibrinogenemia associated with cryopathy. Proceedings of the IXth Congress of the International Society of Hematology, vol. III. Universidad Nacional Autonoma de Mexico, Mexico, 1964, p. 239. Google Scholar4. FAHEY JL: Serum protein disorders causing clinical symptoms in malignant neoplastic disease. J. Chronic Dis. 16: 703, 1963. CrossrefMedlineGoogle Scholar5. OWENBETTERHOBAN JAECJ: A simple method for determination of serum haptoglobins. J. Clin. Path. 13: 163, 1960. CrossrefMedlineGoogle Scholar6. HENRYCHIAMORIJACOBSSEGALOVE RJNSLM: Determination of ceruloplasmin oxidase in serum. Proc. Soc. Exp. Biol. Med. 104: 620, 1960. CrossrefGoogle Scholar7. RATNOFFMENZIE ODC: New method for determination of fibrinogen in small samples of plasma. J. Lab. Clin. Med. 37: 316, 1955. Google Scholar8. POTTERKUFF MEL: Myeloma globulin plasma-cell neoplasms in inbred mice. Immunoelectrophoresis of serum, with rabbit antibody prepared against microsome fractions of the neoplasms. J. Nat. Cancer Inst. 26: 1109, 1961. MedlineGoogle Scholar9. KABATMAYER EAMM: Experimental Immunochemistry, 2nd ed. Charles C Thomas, Publisher, Springfield, Ill., 1961, p. 85. Google Scholar10. WALDMANNLASTER TAL: Abnormalities of albumin metabolism in patients with hypogammaglobulinemia. J. Clin. Invest. 43: 1025, 1964. CrossrefMedlineGoogle Scholar11. STERLINGGRAY KSJ: Determination of the circulating red cell volume in man by radioactive chromium. J. Clin. Invest. 29: 1614, 1950. CrossrefMedlineGoogle Scholar12. MCKEEKALBFLEISCHBIRD PAJMRM: Incidence and significance of cryofibrinogenemia. J. Lab. Clin. Med. 61: 203, 1963. Google Scholar13. HENSTILLFEINSTEIN HHM: Interference of abnormal plasma proteins with clotting mechanism. Amer. J. Med. 22: 381, 1957. CrossrefMedlineGoogle Scholar14. KALBFLEISCHBIRD JMRM: Cryofibrinogenemia. New Eng. J. Med. 263: 881, 1960. CrossrefMedlineGoogle Scholar15. JAGER BV: Cryofibrinogenemia. New Eng. J. Med. 266: 579, 1962. CrossrefMedlineGoogle Scholar16. GLUECKHERRMANN HILG: Cold-precipitable fibrinogen, "cryofibrinogen." Arch. Intern. Med. (Chicago) 113: 748, 1964. CrossrefMedlineGoogle Scholar17. MIDERATLINGMORTON GBELJJ: Effect of neoplastic and allied diseases on the concentration of the plasma proteins. Cancer 3: 56, 1950. CrossrefMedlineGoogle Scholar18. STEINFIELD JL: 131I albumin degradation in patients with neoplastic diseases. Cancer 13: 974, 1960. CrossrefGoogle Scholar19. FURTHSOBEL JH: Hypervolemia secondary to grafted granulosa cell tumor in mice. J. Nat. Cancer Inst. 7: 103, 1946. MedlineGoogle Scholar20. BARTHWOCHNERWALDMANNFAHEY WFRDTAJA: Metabolism of human gamma macroglobulins. J. Nat. Cancer Inst. 43: 1036, 1964. Google Scholar21. GABUZDA TG: The turnover and distribution of I131-labeled myeloma and macroglobulin proteins. J. Lab. Clin. Med. 59: 65, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM BELL, M.D.; RAYMOND BAHR, M.D.; THOMAS A. WALDMANN, M.D.; PAUL P. CARBONE, M.D.Affiliations: Bethesda and Baltimore, MarylandFrom the Medicine Branch and Metabolism Service, National Cancer Institute, Bethesda, Md., and the U. S. Public Health Service Hospital, Baltimore, Md.Requests for reprints should be addressed to William Bell, M.D., Building 10, Room 12N-226, National Institutes of Health, Bethesda, Md. 20014. 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Treatment with HeparinDysfibrinogenemia in a Patient with Primary Hepatoma 1 March 1966Volume 64, Issue 3Page: 658-664KeywordsBlood plasmaFibrinogenHemorrhageHepatocellular carcinomaHospital medicineLaboratory testsLung and intrathoracic tumorsMedical servicesPlasma proteinsRaynaud syndrome ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...