Key result
OSA shows no association with endothelial dysfunction markers in children with sickle cell disease.
Why the study?
Sickle cell disease is characterized by endothelial dysfunction, but the utility of peripheral arterial tonometry to assess this dysfunction in pediatric SCD patients was not well established.
Cross-Sectional (n=120)
No
Answers are grounded in this paper and cite their sources.
High OSA prevalence in pediatric sickle cell disease may warrant screening; leaves open its contribution to endothelial dysfunction.
BACKGROUND: SCD is characterized by hemolysis and oxidative stress, resulting in endothelial dysfunction (EDF). Peripheral arterial tonometry (PAT), a noninvasive technology for measuring EDF, utilizes reactive hyperemia following mini-ischemic stress (reactive hyperemia index or RHI). METHODS: The authors studied PAT in 36 SCD children to determine the influence of hemoglobin genotype and treatment on EDF. RESULTS AND CONCLUSIONS: Blunted RHI was seen in the majority of children with SCD, especially with increased symptomatology (1.53 and 1.71; p value .032). RHI was not normal in children on chronic transfusion or hydroxyurea. RHI correlated with reticulocyte fraction (Spearman r = -.47, p = .037). PAT merits further exploration as a measure of EDF in SCD.
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Sivamurthy et al. (2009) conducted a cross-sectional in Sickle Cell Disease (SCD) and Sleep-Disordered Breathing (n=120). Obstructive sleep apnea (OSA) vs. No OSA was evaluated on Serum TNF-α level (ng/L) (p=0.953). Obstructive sleep apnea was highly prevalent (73.3%) in children with sickle cell disease, but markers of endothelial dysfunction such as TNF-α did not significantly differ between patients with and without OSA.
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