Key result
Coronary lesion location shows no association with quantitative total perfusion deficit values on SPECT.
Why the study?
The reliability of total perfusion deficit (TPD) values for different coronary artery lesion locations in stable coronary artery disease was not previously compared.
Observational (n=133)
No
p-value: p=>0.05
Lesion location does not affect quantitative perfusion deficits; leaves open whether vessel-specific thresholds improve MPI accuracy.
Introduction:In the present study, we analyzed patients with stable coronary artery disease (SCAD) by quantitative myocardial perfusion scintigraphy and evaluated the effect of different coronary lesion locations on total perfusion deficit (TPD).Patients and Methods: A total of 133 consecutive patients with SCAD who underwent myocardial perfusion imaging single photon emission computed tomography (SPECT) and conventional coronary angiography according to SPECT results were included in the study.TPD was used as the automated quantification variable.Results: Of the patients, 61 had significant coronary artery disease, and 72 had normal coronary arteries.For the normal, left anterior descending artery (LAD), circumflex artery (CX), and right coronary artery (RCA) groups, the median values were 7% vs. 11% vs. 10% vs. 9%, 4% vs. 6% vs. 7% vs. 4%, and 3% vs. 5% vs. 6% vs. 3% for stress TPD (sTPD), rest TPD (rTPD), and ischemic TPD (iTPD), respectively.There was no statistically significant difference in quantitative analysis (sTPD, rTPD, and iTPD) between the LAD, CX, and RCA groups (p> 0.05).Conclusion: TPD obtained by quantitative analysis method can be used for all coronary artery lesion location.
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Doğan et al. (2018) conducted an observational in Stable coronary artery disease (n=133). Significant coronary artery lesion location (LAD, CX, or RCA) vs. Normal coronary arteries or alternative lesion locations was evaluated on Stress total perfusion deficit (sTPD) (p=>0.05). Localization of significant coronary artery lesions (LAD, CX, or RCA) had no statistically significant effect on stress, rest, or ischemic total perfusion deficit values obtained by quantitative analysis.
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