In Silico prediction of gene expression based on codon usage: a mini review

The present review deals with the computational approach for estimating the average expression level of proteins in microorganisms. Based on the notion that codon assignment as well as codon usage patterns might play a key role to the solution of practical problems of gene expression, alternative models are proposed and developed to identify the highly expressed genes in diverse genomes. Facts and ideas presented here aims at deriving biological information from genome sequences by means various statistical analyses and appropriate design of algorithms.