Key result
Left ventricular dysplasia is linked to sudden death, with family screening suggesting inheritable involvement.
Why the study?
The association of left ventricular dysplasia with sudden death and its potential inheritable nature were not well established.
Case Report (n=1)
Supports left-dominant ventricular dysplasia in sudden-death evaluation; leaves open prevalence and family screening protocols.
A 32-year-old man who died suddenly and unexpectedly was found at autopsy to have prominent fatty infiltration of his left ventricle with fibrous scarring, in the presence of normal coronary arteries. The right ventricle was minimally involved. A diagnosis of ventricular dysplasia largely limited to the left ventricle was made. Subsequent family screening identified a brother with clinical manifestations of ventricular dysplasia. This case provides further evidence for the association of left ventricular dysplasia with sudden death, and demonstrates that left ventricular involvement may also be inheritable. Whether predominantly left ventricular dysplasia is a manifestation of right ventricular dysplasia, or is a separate entity, is yet to be determined.
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Shrapnel et al. (2001) conducted a case report in Arrhythmogenic Left Ventricular Dysplasia (n=1). Left ventricular dysplasia was evaluated on Sudden death. Left ventricular dysplasia was associated with sudden death in a 32-year-old man, with subsequent family screening demonstrating that left ventricular involvement may be inheritable.
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