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The development of pharmacological substances, capable of exerting powerful effects at known sites in the nervous system, has provided a new versatile tool for clinical research. No longer is it necessary to destroy a part of the nervous system in order to study what effect it may have upon a phenomenon; the activity of that part may be held in abeyance by the use of pharmacological blocking agents. Like-wise, stimulation no longer always demands the application of electrodes; drugs acting at a specific site provide a more elegant experiment. But the supreme advantage is that these methods can be applied to man, thus eliminating the many pitfalls which arise when human problems are studied in other species.
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C. Constas (1962) studied this question.
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