Key result
Elevated hs-cTnT is linked to ~2-fold higher 30-day mortality in severe COVID-19.
Why the study?
The prognostic value of cardiac troponin T levels for mortality in hospitalized COVID-19 patients across different sex and age groups was unclear.
Does elevated high-sensitivity cardiac troponin T predict 30-day mortality in hospitalized patients with severe COVID-19?
Cohort (n=1,231)
Yes
Does elevated high-sensitivity cardiac troponin T predict 30-day mortality in hospitalized patients with severe COVID-19?
Odds Ratio: 2 (95% CI 1.53–2.62)
Absolute Event Rate: 38.8% vs 23.8%
p-value: p=<0.001
Elevated high-sensitivity cardiac troponin T is a strong, independent predictor of 30-day mortality in patients hospitalized with severe COVID-19, with prognostic value remaining robust across sex and age groups.
May aid prognostication in severe COVID-19; leaves open whether troponin-guided interventions improve outcomes.
Objective To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age. Methods We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1,050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April-August 2020) of the COVID-19 pandemic. Results We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age. Conclusion These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups. Clinical Trials registration number NCT04338360 Clinical Perspective This study evaluated the prognostic value of elevated hs-cTnT in patients hospitalized with COVID-19 who received convalescent plasma. There was a continuous relationship between elevated hs-cTnT values and mortality in both males and females hospitalized for COVID-19. The magnitude of the prognostic value of elevated hs-cTnT varied by sex and age, suggesting that these covariates are important to consider in this population.
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Bruno et al. (2025) conducted a cohort in Severe or life-threatening COVID-19 (n=1,231). Elevated high-sensitivity cardiac troponin T (hs-cTnT) vs. Normal hs-cTnT levels was evaluated on 30-day mortality (Adjusted OR 2.00, 95% CI 1.53-2.62, p=<0.001). Elevated high-sensitivity cardiac troponin T levels were associated with a significant two-fold increase in the odds of 30-day mortality (Adjusted OR 2.00) in patients hospitalized with severe COVID-19.
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