Key result
Elevated high sensitivity cardiac troponin I (>40 ng/L) was associated with a lower one-week survival rate (59.27%) compared to values <6 ng/L (97.94%) in patients with COVID-19 (P<0.001).
Why the study?
Complications have been reported in COVID-19 patients with worse prognosis, prompting evaluation of the role of high sensitivity cardiac troponin I in patients with SARS-CoV-2 infection.
Does elevated high sensitivity cardiac troponin I (hs-TnI) predict mortality in patients with COVID-19?
Cohort (n=523)
No
Does elevated high sensitivity cardiac troponin I (hs-TnI) predict mortality in patients with COVID-19?
Absolute Event Rate: 59.27% vs 97.94%
p-value: p=<0.001
Elevated high sensitivity cardiac troponin I is associated with significantly increased short-term mortality in patients hospitalized with COVID-19.
Elevated hs-TnI signals higher mortality risk in COVID-19; leaves open whether troponin monitoring improves risk stratification.
BACKGROUND: Severe pneumonia is pathological manifestation of Coronavirus Disease 2019 (COVID-19), however complications have been reported in COVID-19 patients with a worst prognosis. Aim of this study was to evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection. METHODS: we retrospectively analysed hs-TnI values measured in 523 patients (median age 64 years, 68% men) admitted to a university hospital in Milan, Italy, and diagnosed COVID-19. RESULTS: < 0.001). The survival rate, after one week, in patients with hs-TnI values under 6 ng/L was 97.94%, between 6 ng/L and the normal value was 90.87%, between the normal value and 40 ng/L was 86.98, and 59.27% over 40 ng/L. CONCLUSION: Increase of hs-TnI associated with elevated mortality in patients with COVID-19. Troponin shows to be a useful biomarker of disease progression and worse prognosis in COVID-19 patients.
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Salvatici et al. (2020) conducted a cohort in COVID-19 (n=523). High sensitivity cardiac troponin I (hs-TnI) > 40 ng/L vs. hs-TnI < 6 ng/L was evaluated on One-week survival rate (p=<0.001). Elevated high sensitivity cardiac troponin I (>40 ng/L) was associated with a lower one-week survival rate (59.27%) compared to values <6 ng/L (97.94%) in patients with COVID-19 (P<0.001).
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