Key result
Perioperative beta-blockers show nuanced role in preventing myocardial infarction during noncardiac surgery.
Why the study?
Perioperative myocardial infarction is a major cause of complications and death among patients undergoing noncardiac surgery, with unclear optimal management strategies.
Answers are grounded in this paper and cite their sources.
Offers no new data to guide perioperative beta-blocker use; leaves open critical questions for future research.
Perioperative myocardial infarction is a major cause of complications and death among patients undergoing noncardiac surgery.1 Annually in the United States, approximately 27 million patients are given anesthesia for surgical procedures; of these, approximately 50,000 patients have a perioperative myocardial infarction.2 The pathophysiology of an acute perioperative myocardial infarction is probably the same as it is for infarction unrelated to surgery.3 In patients with clinically significant coronary-artery stenosis, myocardial ischemia is induced either by a prolonged mismatch between oxygen demand and supply owing to the stress of surgery or as the result of a sudden rupture of a vulnerable plaque . . .
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Poldermans et al. (2005) conducted a review in Perioperative myocardial infarction in noncardiac surgery. Beta-Blocker Therapy was evaluated. Beta-blocker therapy is reviewed in the context of perioperative myocardial infarction, a major cause of complications and death among patients undergoing noncardiac surgery.
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