Key result
Progressive metastatic breast cancer linked to ~50% higher free fatty acids in post-menopausal women.
Why the study?
Pretreatment circulating lipids and lipoproteins and their fatty acid composition in post-menopausal women with metastatic breast cancer were not well characterized.
Case-Control
Effect estimate: 1.5 times higher free fatty acids; 14% lower total cholesterol
Lipid differences in metastatic breast cancer are hypothesis-generating; prospective studies needed to clarify prognostic or therapeutic relevance.
Pretreatment values of circulating lipids and lipoproteins and their fatty acid composition were characterized in post-menopausal women with progressive metastatic breast cancer. Circulating free fatty acids averaged 1½ times the mean value in healthy post-menopausal women. Levels of plasma total cholesterol and beta- +pre-beta-lipoprotein cholesterol were 14% less in women with breast cancer. Levels of triglycerides and phospholipids were similar in both groups. There was a relative increase in alpha-lipoprotein in cancer patients. Fatty acid compositions of free fatty acids and alpha- and beta- +pre-beta-lipoprotein triglycerides, phospholipids and cholesterol esters were similar to those of healthy women in women with breast cancer. Lipid alterations could not be correlated significantly with menopausal age, dominant metastatic lesion or outcome of treatment. Chronic adipokinesis may be attributable to abnormal metabolic regulation by a variety of hormones, related in some way to the activity of the breast carcinoma.
No takes yet. Share an insight, caveat, or question.
FELDMAN et al. (1971) conducted a case-control in Metastatic breast cancer. Metastatic breast cancer vs. Healthy post-menopausal women was evaluated on Circulating free fatty acids and plasma total cholesterol (1.5 times higher free fatty acids; 14% lower total cholesterol). Post-menopausal women with progressive metastatic breast cancer had circulating free fatty acid levels 1.5 times higher and plasma total cholesterol levels 14% lower than healthy post-menopausal women.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: