Key result
Cardiac [(1)H]-MRS with 64 signal averages was highly feasible for quantifying intramyocardial triglyceride, showing excellent agreement with the 128-average reference standard while significantly reducing scan duration from 13.2 to 5.9 minutes (p<0.001).
Why the study?
Quantification of intramyocardial metabolites by proton magnetic resonance spectroscopy is limited by long scan durations and technical challenges, and the feasibility and accuracy of using fewer signal averages were unknown.
Does cardiac [(1)H]-MRS with fewer signal averages improve scan times while maintaining feasibility and accuracy for quantifying intramyocardial metabolites in healthy volunteers?
Cross-Sectional (n=31)
Does cardiac [(1)H]-MRS with fewer signal averages improve scan times while maintaining feasibility and accuracy for quantifying intramyocardial metabolites in healthy volunteers?
Absolute Event Rate: 5.9% vs 13.2%
p-value: p=<0.001
Intramyocardial triglyceride can be accurately quantified using cardiac [(1)H]-MRS with only 64 signal averages, significantly reducing scan duration, but 128 averages remain necessary for creatine and choline.
Supports shorter triglyceride MRS protocols in volunteers; leaves open validation for other metabolites and clinical populations.
PURPOSE: To define intramyocardial triglyceride (TG), creatine (Cr), and choline (Cho) in healthy volunteers, and determine the feasibilities, scan durations and agreements between cardiac proton magnetic resonance spectroscopy ([(1)H]-MRS) performed with fewer signal averages versus a reference standard with 128 signal averages. MATERIALS AND METHODS: Thirty-one participants underwent [(1)H]-MRS using 16, 32, 64, and 128 signal averages. Intramyocardial TG, Cr, or Cho contents relative to water were calculated and expressed as a percentage. RESULTS: Mean intramyocardial TG, Cr, and Cho were 1.30 ± 1.13, 0.19 ± 0.18, and 0.24 ± 0.28%, respectively. The feasibilities for quantifying intramyocardial TG, Cr, and Cho using fewer signal averages ranged from 93.5 to 100, 90.3 to 93.5, and 90.3 to 96.8%, respectively. Scan durations for 16, 32, 64, and 128 signal averages were 1.1 ± 0.5, 2.6 ± 0.9, 5.9 ± 2.0, and 13.2 ± 4.5 min, respectively (p < 0.001). Agreements with the reference standard 128 signal average was higher for quantification of intramyocardial TG compared to Cr and Cho. CONCLUSION: Quantification of intramyocardial TG with [(1)H]-MRS with only 64 signal averages was highly feasible, showed excellent agreement with 128 signal averages, and had significantly shorter scan duration. By contrast, quantifying Cr and Cho using fewer signal averages had lower feasibilities and agreements compared to 128 signal averages.
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Gillinder et al. (2015) conducted a cross-sectional in Healthy volunteers (n=31). Cardiac proton magnetic resonance spectroscopy ([(1)H]-MRS) with 64 signal averages vs. [(1)H]-MRS with 128 signal averages was evaluated on Scan duration (p=<0.001). Cardiac [(1)H]-MRS with 64 signal averages was highly feasible for quantifying intramyocardial triglyceride, showing excellent agreement with the 128-average reference standard while significantly reducing scan duration from 13.2 to 5.9 minutes (p<0.001).
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