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September 23, 2004Antimicrobial Agents and ChemotherapyOpen Access

Determination of Susceptibilities of 26Leptospirasp. Serovars to 24 Antimicrobial Agents by a Broth Microdilution Technique

Clinton K. Murray Duane R. Hospenthal

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Abstract

The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC(90)s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all </=0.01 microg/ml. The MIC(90)s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were >/=3.13 microg/ml. Many antimicrobials have excellent in vitro activity against Leptospira.

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Murray et al. (2004) studied this question.

synapsesocial.com/papers/6acedb573662e7de35f89ccb https://doi.org/10.1128/aac.48.10.4002-4005.2004

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