Weekly hypofractionated radiation therapy in elderly non-resectable cutaneous squamous cell carcinoma of the head and neck region

INTRODUCTION: Treatment of inoperable cutaneous squamous cell carcinoma (cSCC) of the head and neck region is still debated. CASE REPORT: We report an original case of cure of cSCC of the head and neck region with weekly hypofractionated radiation therapy with megavoltage electrons prescribed for locally advanced inoperable disease. RESULTS: Weekly hypofractionated radiotherapy assured complete regression and was well-tolerated. CONCLUSION: The real efficacy of this treatment in the therapeutic arsenal remains to be defined. A clinical trial is ongoing to test the use of 8 weekly fractions of 8 Gy hypofractionated RT regimens in non-resectable cSCC cases.