Serum Uric Acid and Spot Urinary Calcium–Creatinine Ratio in Hypertensive Disorders of Pregnancy: A Comparative Study

Q: What are the key findings of this study?

Hypertensive disorders of pregnancy were associated with significantly elevated serum uric acid (6.21 vs 4.12 mg/dL) and reduced spot urinary calcium/creatinine ratios (0.075 vs 0.124) compared to normal pregnancy.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertensive disorders of pregnancy (n=50). Intervention: Hypertensive disorders of pregnancy vs. Normotensive pregnancy. Primary outcome: Serum uric acid (mg/dL) (p=<0.001).

Q: What does this research mean for the field?

Women with hypertensive disorders of pregnancy have significantly elevated serum uric acid levels and lower spot urinary calcium-to-creatinine ratios compared to normotensive pregnant women. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To determine serum uric acid and spot urinary calcium/creatinine ratio in women with hypertensive disorders of pregnancy compared with normotensive pregnant women.

Golagani Kiranmai; Namada Pradeepa; V Bhanu Prasad; Vanja Swarnalatha; Amrutha Satyavarapu

doi:10.67170/jmmdt.2026.v2i10.003

October 12, 2026Journal of Medicine Pharmacology and Medical Devises TechnologyOpen Access

Serum Uric Acid and Spot Urinary Calcium–Creatinine Ratio in Hypertensive Disorders of Pregnancy: A Comparative Study

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Key result

Hypertensive disorders of pregnancy linked to ~2.1 mg/dL higher serum uric acid vs normal pregnancy.

P<0.001
n=50

Why the study?

Hypertensive disorders of pregnancy contribute significantly to maternal and perinatal morbidity, and simple biochemical parameters for their assessment are needed.

Are serum uric acid and spot urinary calcium/creatinine ratio significantly altered in pregnant women with hypertensive disorders compared to normotensive pregnancies?

Key Points

To determine serum uric acid and spot urinary calcium/creatinine ratio in women with hypertensive disorders of pregnancy compared with normotensive pregnant women.
Conducted a hospital-based comparative cross-sectional study of 50 pregnant women, consisting of 25 women with hypertensive disorders of pregnancy and 25 normotensive pregnant women.
Documented demographic, obstetric, and clinical parameters including blood pressure and proteinuria status.
Collected venous blood for serum uric acid estimation and clean-catch midstream spot urine for calcium and creatinine estimation to calculate the urinary calcium/creatinine ratio.
Mean serum uric acid was significantly higher in women with hypertensive disorders (6.21 ± 1.08 mg/dL) than in normotensive controls (4.12 ± 0.74 mg/dL), with levels >5.5 mg/dL found in 72.0% versus 16.0% of participants, respectively.
Mean urinary calcium was significantly lower in the hypertensive group (6.84 ± 2.16 mg/dL) than in normotensive women (10.92 ± 3.24 mg/dL), as was the urinary calcium/creatinine ratio (0.075 ± 0.028 vs. 0.124 ± 0.041).
Both elevated serum uric acid and low urinary calcium/creatinine ratio were present concurrently in 52.0% of hypertensive women compared with 8.0% of normotensive women, while urinary creatinine levels did not differ significantly between groups.

Study Design

Type

Cross-Sectional (n=50)

Multicenter

No

Structured PICO

Are serum uric acid and spot urinary calcium/creatinine ratio significantly altered in pregnant women with hypertensive disorders compared to normotensive pregnancies?

P

Population

50 pregnant women aged over 18 years with a singleton pregnancy after 24 weeks of gestation, comparing 25 with hypertensive disorders to 25 normotensive controls.

E

Exposure

Hypertensive disorders of pregnancy (pregnancy-induced hypertension or pre-eclampsia)

C

Comparator

Normotensive pregnant women without proteinuria or clinical features of hypertensive disorders

O

Outcome

Serum uric acid levels and spot urinary calcium/creatinine ratiosurrogate

Main Result

Absolute Event Rate: 6.21% vs 4.12%

p-value: p=<0.001

Serum uric acid and spot urinary calcium/creatinine ratio are simple and accessible biochemical markers that are significantly altered in pregnant women with hypertensive disorders, aiding in disease evaluation.

Limitations

Small sample size (n=50)
Convenience sampling
Hospital-based setting may limit generalizability

Implication

Should not yet alter evaluation of hypertensive disorders of pregnancy; leaves open the utility of uric acid and urinary calcium/creatinine ratios as markers.

Abstract

Background: Hypertensive disorders of pregnancy are major contributors to maternal and perinatal morbidity. Serum uric acid and spot urinary calcium/creatinine ratio are simple biochemical parameters that may help in assessment of these disorders. Aim: To determine serum uric acid and urinary calcium/creatinine ratio in hypertensive disorders of pregnancy and in normal pregnant women. Methods: This hospital-based comparative cross-sectional study was conducted among 50 pregnant women, including 25 women with hypertensive disorders of pregnancy and 25 normotensive pregnant women. Demographic, obstetric and clinical details were recorded. Blood pressure and proteinuria status were documented. Venous blood was collected for serum uric acid estimation, and clean-catch midstream spot urine was collected for urinary calcium and creatinine estimation. Urinary calcium/creatinine ratio was calculated. Results: Serum uric acid was significantly higher in the hypertensive group compared with controls. Urinary calcium and urinary calcium/creatinine ratio were significantly lower among women with hypertensive disorders. Urinary creatinine showed no significant difference between the groups. Conclusion: Serum uric acid and spot urinary calcium/creatinine ratio may serve as simple supportive biochemical markers in the evaluation of hypertensive disorders of pregnancy.

Discussion

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Cite This Study

Kiranmai et al. (2026) conducted a cross-sectional in Hypertensive disorders of pregnancy (n=50). Hypertensive disorders of pregnancy vs. Normotensive pregnancy was evaluated on Serum uric acid (mg/dL) (p=<0.001). Hypertensive disorders of pregnancy were associated with significantly elevated serum uric acid (6.21 vs 4.12 mg/dL) and reduced spot urinary calcium/creatinine ratios (0.075 vs 0.124) compared to normal pregnancy.

synapsesocial.com/papers/6acf0f522fe143470d0586e4 https://doi.org/10.67170/jmmdt.2026.v2i10.003

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Serum Uric Acid and Spot Urinary Calcium–Creatinine Ratio in Hypertensive Disorders of Pregnancy: A Comparative Study

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Serum Uric Acid and Spot Urinary Calcium–Creatinine Ratio in Hypertensive Disorders of Pregnancy: A Comparative Study

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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