Key result
Gestational hypertension is linked to ~5 mL/min/1.73m2 lower mean eGFR during pregnancy.
Why the study?
Hypertensive disorders of pregnancy affect serum creatinine, uric acid, and eGFR, but evidence supporting these associations in a Sri Lankan pregnant population was limited.
Does evaluation of serum creatinine, serum uric acid, and eGFR differentiate gestational hypertension from normotensive pregnancy in third-trimester singleton pregnant women in Sri Lanka?
Case-Control (n=62)
Single-blind (laboratory personnel blinded to biochemical analyses)
No
Does evaluation of serum creatinine, serum uric acid, and eGFR differentiate gestational hypertension from normotensive pregnancy in third-trimester singleton pregnant women in Sri Lanka?
In third-trimester Sri Lankan pregnant women, reduced eGFR and elevated serum creatinine are significantly associated with gestational hypertension, with eGFR demonstrating the best diagnostic accuracy (AUC 0.72) for detecting subclinical renal impairment.
Background: Hypertensive disorders of pregnancy (HDPs), a major complication during pregnancy, affect serum creatinine, uric acid levels, as well as estimated glomerular filtration rate (eGFR). However evidence supporting these associations in the Sri Lankan context remains limited. Therefore the present study investigated these renal parameters in HDPs, in a selected Sri Lankan pregnant population.Method: A case-control study was conducted at a tertiary care hospital in 31 normotensive and 31 gestational hypertensive pregnant women, all in their third trimester singleton pregnancy. Serum creatinine and uric acid levels were measured using a kinetic enzymatic colorimetric method and eGFR levels were calculated using the CKD-EPI equation. Pooled t-test, Spearman correlation test and Receiver Operating Characteristic (ROC) curves were the statistical tests performed using SPSS software. p<0.05 was deemed significant.Results: The mean serum creatinine between normotensive and gestational hypertensive pregnant women was significantly different (0.55±0.06 mg/dL vs. 0.60±0.09 mg/dL; p=0.037). The mean serum uric acid levels were not statistically significant. There was a significant difference in the mean eGFR between the cases and controls (127.42±4.98 ml/min/1.73m2 vs. 122.26±8.07 ml/min/1.73m2; p=0.004), respectively. The ROC curves did not show a significant Area Under the Curve (AUC) for serum creatinine and uric acid in HDP [AUC=0.66 and 0.52, respectively]. However, eGFR showed a significant performance in differentiating HDP (AUC=0.72, p=0.003).Conclusion: Lower eGFR levels and higher serum creatinine levels are associated with gestational hypertensive pregnancies compared to normotensive pregnancies. eGFR levels are more reliable, aiding early detection of renal impairment and potentially reducing chronic kidney disease (CKD) risks in hypertensive pregnant women.
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Fawaziya et al. (2026) conducted a case-control in Hypertensive disorders of pregnancy (gestational hypertension) (n=62). Gestational hypertension vs. Normotensive singleton pregnancy was evaluated on Estimated glomerular filtration rate (eGFR, ml/min/1.73m2) and diagnostic performance (ROC AUC) for differentiating gestational hypertension (AUC 0.72, 95% CI 0.59-0.85, p=0.004). Gestational hypertension was associated with lower mean eGFR (122.26 vs 127.26 mL/min/1.73m2, p=0.004; AUC 0.72) and higher serum creatinine (0.60 vs 0.55 mg/dL, p=0.037) than normotensive pregnancy.
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