Key result
The protein/creatinine ratio detected renal impairment in 100% of hypertensive expectant mothers, whereas urine dipstick testing only detected significant proteinuria in 66.6% of cases.
Why the study?
The study was conducted to determine the prevalence of renal impairment using the protein/creatinine ratio among expectant mothers with renal vascular disease.
Does protein/creatinine ratio improve the detection of renal impairment compared to urine test strips in hypertensive expectant mothers?
Cross-Sectional (n=69)
No
Does protein/creatinine ratio improve the detection of renal impairment compared to urine test strips in hypertensive expectant mothers?
Protein/creatinine ratio is more sensitive than standard urine dipstick for detecting proteinuria and diagnosing renal impairment in hypertensive pregnant women.
Protein/creatinine ratio may improve proteinuria detection in hypertensive pregnancies; hypothesis-generating and requires prospective validation before practice change.
Objective: Determine the prevalence of renal impairment after calculating protein/creatinine ratio among expectant mothers with renal vascular disease. Method:It was a descriptive cross-sectional study conducted in the Obstetrics and Gynecology University Clinic (CUGO) of CNHU-HKM from April 3, 2017 to August 3, 2017.Patients included in this study wereexpectant motherswho reported to the hospital for either antenatal or emergency consultation in CUGO, with high of blood pressure ≥ 140/90 mmHg.They all gave their informed consent to take part in this clinical research.Nonprobabilistic sampling was conducted, and expectant mothers meeting our inclusion criteria were included in the study.Data were collected on paper using the questionnaire, and then entered into Epi-Data version 3.1.Then, Epi-Data 2.2.2.182 and OpenEpi 3.01 were used for data analysis.Outcomes: Among the 105 expectant mothers selected, 69 met our inclusion criteria.Theexpectant mothers aged ranged from 14 to 42 years, with mean age estimated at 28 ± 6.5 years.Globally, 7.41% of the expectant mothers had hypertension.Referral was the leading mode of admission to hospital.Headache was reported as themost frequent reason for consultation by 40.6% of patients.Hypertension occurred predominantly after 20 weeks gestation with approximately 71% of patients.Preeclampsia was the major diagnosis (approximately 68% of cases).Dipstick proteinuriawas significant for 46 expectant mothers,i.e.66.6% of cases.For all cases, renal impairment was confirmed by using protein/creatinine ratio. Conclusion:Protein/creatinine ratio helps to diagnose renal impairmentearly enoughin case of renal vascular disease.
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BL et al. (2019) conducted a cross-sectional in Hypertensive disorders of pregnancy (n=69). Protein/creatinine ratio vs. Urine dipstick was evaluated on Detection of renal impairment (significant proteinuria). The protein/creatinine ratio detected renal impairment in 100% of hypertensive expectant mothers, whereas urine dipstick testing only detected significant proteinuria in 66.6% of cases.
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