Key result
Reduced β-adrenergic reactivity after catheter ablation is linked to absence of residual ventricular extrasystoles.
Why the study?
Ventricular arrhythmias in children have a high recurrence rate after radiofrequency ablation, and the role of erythrocyte membrane β-adrenergic reactivity in personalizing management is unclear.
Can erythrocyte membrane β-adrenergic reactivity predict the recurrence of ventricular arrhythmias in children after radiofrequency ablation?
Observational (n=10)
No
Can erythrocyte membrane β-adrenergic reactivity predict the recurrence of ventricular arrhythmias in children after radiofrequency ablation?
Evaluating β-adrenergic reactivity of erythrocyte membranes may help identify the risk of long-term ventricular arrhythmia recurrence in pediatric patients following radiofrequency ablation, guiding personalized follow-up care.
β-ARM reduction post-RFA was associated with absent residual VE in children; hypothesis-generating for recurrence prediction in larger cohorts.
Background. Ventricular arrhythmias (VA) in children are characterized by a high recurrence rate after radiofrequency ablation (RFA). Given the important role of autonomic dysregulation in arrhythmogenesis, the erythrocyte membrane β-adrenergic reactivity (β-ARM), reflecting β-adrenergic receptor desensitization, can be used to personalize approaches to the management of pediatric patients. Aim: To analyze the relationship between residual ectopic activity (EA) and VA recurrence in children before, on the third day, and in the late period after RFA with β-ARM levels. Material and Methods. Ten patients aged 9–17 years with VA (EA >10%) were included. β-ARM levels and the presence of ventricular extrasystoles (VEPs) based on Holter ECG monitoring were determined before RFA, on the third day, and 6–18 months after RFA. One obese patient was excluded from the β-ARM analysis. Results. Recurrent VEPs (≥10%) were recorded in 2 patients (20%), with residual activity <10% in 2 patients (20%). Visually, the baseline β-ARM was lower in patients without recurrence. Early changes in β-ARM were chaotic (influence of stress, anesthesia). In the late period, two zones were identified: ≤8.97 conventional units (absence of VEPs, n=5) and ≥13.68 conventional units (residual activity 5–19%, n=4). A statistically significant reduction in β-ARM was observed only in the group without VES (p=0.043). Conclusion. Low preoperative β-ARM is associated with a favorable outcome, and long-term zonation and reduction in patients free of recurrence confirm the reversibility of sympathetic hyperactivation. β-ARM can be used to personalize follow-up care in children after RFA.
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Yakimova et al. (2026) conducted an observational in Ventricular arrhythmias (VA) (n=10). Erythrocyte membrane β-adrenergic reactivity (β-ARM) was evaluated on Change in β-ARM levels in the late period after radiofrequency ablation in patients without vs with recurrent ventricular extrasystoles (p=0.043). In the late period after radiofrequency ablation, a statistically significant reduction in β-adrenergic reactivity of erythrocyte membranes was observed only in the group of patients without residual ventricular extrasystoles (p=0.043).
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