Key result
IVIG plus methylprednisolone resolves fulminant myocarditis and normalizes biomarkers in neonatal lupus.
Why the study?
Neonatal thrombosis is a rare manifestation with unclear aetiology, particularly in neonatal lupus associated with maternal antiphospholipid antibodies.
Case Report (n=1)
May support IVIG plus methylprednisolone for fulminant myocarditis in neonatal lupus; leaves open need for controlled trials.
Neonatal thrombosis is considered a rare manifestation with unclear aetiology. We reported a neonatal lupus of a Sjogren's syndrome mother with recurrent miscarriage secondary to antiphospholipid syndrome; seronegative to anticardiolipin antibodies, lupus anticoagulant and B2GP1. She was serologically positive to antiphosphatidylethanolamine and antiprothrombin antibodies, anti-SSA/Ro and anti-SSB/La. The neonate developed neonatal lupus complicated with right ventricular thrombus assumed to be induced by maternal transmission of antiphosphatidylethanolamine and antiprothrombin antibodies, treated successfully with tissue plasminogen activator and warfarin.
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Elnady et al. (2019) conducted a case report in Neonatal lupus erythematosus and fulminant myocarditis (n=1). Intravenous immunoglobulin and methylprednisolone was evaluated. Treatment with intravenous immunoglobulin and methylprednisolone resulted in clinical recovery and normalized cardiac biomarkers in an infant with neonatal lupus and fulminant myocarditis.
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