Why the study?
Low pyrophosphate levels in pseudoxanthoma elasticum may cause ectopic mineralization leading to clinical complications, and etidronate as a pyrophosphate analog might reduce this mineralization.
Population
74 adults with PXE and leg arterial calcifications
Comparison
Etidronate vs placebo
Design
Randomized trial
Follow-up
12 months
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Kranenburg et al. (2018) studied this question.
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