Key result
Left atrial enlargement is linked to ~50% higher incidence of esophageal medication hold up.
Why the study?
It was unclear whether dysphagia occurs in patients with an enlarged left atrium undergoing mitral valve surgery.
Observational (n=80)
Absolute Event Rate: 50% vs 0%
Enlarged left atrium was associated with esophageal hold-up in half of mitral patients; supports link but leaves open need for prospective confirmation before practice change.
Eighty patients were studied to determine whether dysphagia (delayed transit through oesophagus) occurs in the presence of an enlarged left atrium. Twenty-six patients (group A), with no enlargement of the left atrium but undergoing open heart surgery, were randomly selected as controls. Group B (N = 54) consisted of patients undergoing mitral valve surgery with varying degrees of left atrial enlargement. All patients were requested to swallow, in the standing position, a barium filled capsule or barium filled Slow K tablets. If there was no hold up in the oesophagus the procedure was repeated with the patient seated. When hold up occurred the patient was screened at 5, 10 and 15 min. No hold up was found in any patient in the control group (N = 26). 50% of patients with left atrial enlargement had some degree of hold up, the incidence and duration of which correlated with the size of the atrium. Hold up was just as likely to occur with a capsule or with a 'slow K' tablet. When hold up lasted for more than 15 min, water did not flush away the 'stuck' medicament, but a bolus of solid food did.
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PR et al. (1984) conducted an observational in Mitral valve disease with left atrial enlargement (n=80). Left atrial enlargement vs. No left atrial enlargement was evaluated on Hold up in the oesophagus (delayed transit). Left atrial enlargement was associated with a 50% incidence of esophageal hold up of swallowed medicaments, compared to 0% in control patients without left atrial enlargement.
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