Key result
Circulating endothelial cell quantification at 48 hours post-AMI accurately predicts MACE and death.
Why the study?
Quantification of circulating endothelial cells is developing as a novel method to assess endothelial damage and dysfunction in cardiovascular disease, but its clinical implications require clarification.
Does the quantification of circulating endothelial cells assess endothelial dysfunction and predict major adverse events in patients with cardiovascular disease?
Does the quantification of circulating endothelial cells assess endothelial dysfunction and predict major adverse events in patients with cardiovascular disease?
Quantification of circulating endothelial cells provides a novel, reproducible method for assessing endothelial dysfunction and predicting adverse outcomes in cardiovascular disease.
Quantification of circulating endothelial cells (CECs) in peripheral blood is developing as a novel and reproducible method of assessing endothelial damage/dysfunction. The CECs are thought to be mature cells that have detached from the intimal monolayer in response to endothelial injury and are a different cell population to endothelial progenitor cells (EPCs). The EPCs are nonleukocytes derived from the bone marrow that are believed to have proliferative potential and may be important in vascular regeneration. Currently accepted methods of CEC quantification include the use of immunomagnetic bead separation (with cell counting under fluorescence microscopy) and flow cytometry. Several recent studies have shown increased numbers of CECs in cardiovascular disease and its risk factors, such as unstable angina, acute myocardial infarction, stroke, diabetes mellitus, and critical limb ischemia, but no change in stable intermittent claudication, essential hypertension, or atrial fibrillation. Furthermore, CEC quantification at 48 h after acute myocardial infarction has been shown to be an accurate predictor of major adverse coronary events and death at both 1 month and 1 year. This article presents an overview of the pathophysiology of CECs in the setting of cardiovascular disease and a brief comparison with EPCs.
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Boos et al. (2006) conducted a review in Cardiovascular disease. Circulating endothelial cells (CECs) was evaluated. Circulating endothelial cell quantification at 48 hours after acute myocardial infarction accurately predicts major adverse coronary events and death at both 1 month and 1 year.
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