Evaluation of outcomes of obstetric patients with COVID-19 disease followed up in the intensive care unit

Objective: We aimed to evaluate the characteristics, prognosis, laboratory parameters, and mortality of severely ill obstetric patients due to severe COVID-19 disease and determine the factors affecting mortality. Methods: Medical records of obstetric patients with COVID-19 infection were reviewed. Patients were admitted to the intensive care unit (ICU) and the outcomes of the newborns were evaluated furtherly. Results: A total of 325 women were included. The ICU requirement was 8.6% (28/325). Among 28 women admitted to ICU maternal mortality rate was 53.6% (15/28), and preterm delivery rate was 88% (24/28). The 27 newborns were evaluated furtherly. Six stillbirths occurred. 40.7% (11/27) of the newborns had 1st minute APGAR scores lower than 7, while 33.3% (9/27) of them had 5th minute APGAR scores lower than 7. Body mass index, CRP, D-dimer, LDH, and CRP/Alb ratio were found to be significantly higher in the mortality cohort than surviving women requiring ICU. The CRP/Alb ratio was the most significant predictor of COVID-19-related maternal death in ICU. Conclusion: The study revealed that COVID-19-related maternal mortality is considerably high in severely ill patients. The CRP/Alb ratio is a significant predictor of mortality. The cesarean section and preterm delivery rates were significantly high in severely ill mothers with COVID-19. Additionally, the severity of the mothers’ illness negatively influenced neonatal outcomes.