Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.