OBJECTIVE: gene polymorphisms and the efficacy and plasma concentrations of perampanel (PER) in pediatric patients with refractory epilepsy (RE). METHODS: genotypes were detected using first-generation Sanger sequencing, and the plasma concentration of PER was measured using ultra-performance liquid chromatography-tandem mass spectrometry. RESULTS: = 0.027). CONCLUSION: genotypes and PER plasma concentration monitoring provide a promising treatment strategy for Chinese patients with RE.
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Zhao et al. (2026) studied this question.
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