Key result
ApoE epsilon 4 homozygosity is linked to ~16-fold higher prevalence in young men with premature CAD.
Why the study?
The role of apolipoprotein E epsilon 4 allele homozygosity in premature ischaemic heart disease risk in young men was unclear.
Does inheritance of the apolipoprotein E epsilon 4 allele confer an increased risk of premature ischemic heart disease in young men?
Case-Control (n=263)
Does inheritance of the apolipoprotein E epsilon 4 allele confer an increased risk of premature ischemic heart disease in young men?
Effect estimate: 16-fold increase
Apolipoprotein E epsilon 4 homozygosity is strongly associated with a significantly increased risk of premature ischemic heart disease in young men.
We have compared apolipoprotein E gene polymorphism in 91 Australian men aged 30-50 who had been referred for coronary angioplasty and in 172 healthy younger men. 5 of the 19 patients who were less than 40 years of age were homozygous for the epsilon 4 allele, representing a 16-fold increase in prevalence compared with controls. In patients aged 40-50 the epsilon 4 allele frequency was 60% higher than it was in controls. Inheritance of epsilon 4 seems to confer risk of premature ischaemic heart disease in males, homozygotes being especially at risk at a younger age.
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BOCKXMEER et al. (1992) conducted a case-control in Coronary heart disease (n=263). Apolipoprotein epsilon 4 allele homozygosity vs. Healthy younger men (controls) was evaluated on Prevalence of apolipoprotein epsilon 4 allele homozygosity (16-fold increase). Apolipoprotein epsilon 4 homozygosity was present in 26% (5 of 19) of male patients under 40 referred for angioplasty, representing a 16-fold increase in prevalence compared with healthy controls.
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