Key result
Early losartan prevents systolic blood pressure elevation and renal dopaminergic alterations in high-fat-fed rats.
Why the study?
High-fat diet intake triggers renal dopaminergic system and renin–angiotensin system alterations contributing to blood pressure elevation and renal injury, and the potential protective effect of losartan on these changes was investigated.
Does losartan prevent renal dopaminergic system alterations, blood pressure elevation, and renal injury in male Sprague-Dawley rats on a high-fat diet?
Does losartan prevent renal dopaminergic system alterations, blood pressure elevation, and renal injury in male Sprague-Dawley rats on a high-fat diet?
In a rat model of high-fat diet consumption, early losartan administration prevented systolic blood pressure elevation and attenuated renal inflammation and interstitial fibrosis.
Answers are grounded in this paper and cite their sources.
Losartan prevents HFD-induced renal injury in rats; hypothesis-generating for nephroprotection in human obesity-related disease.
The renal dopaminergic system (RDS) promotes natriuresis, diuresis, and exerts anti-inflammatory effects. High-fat diet (HFD) intake triggers the renin–angiotensin system (RAS). The aim of this study was to determine whether losartan (L) prevents RDS-RAS alteration and its impact on blood pressure and renal injury induced by HFD. Male Sprague–Dawley rats studied for 8 weeks were assigned to four groups: control (C; n = 4); HFD (n = 6): 50% w/w of bovine fat added to the standard diet; control + losartan (CL; n = 4): 30 mg/kg/day of L dissolved in drinking water; and HFD + losartan (HFDL; n = 6): HFD + CL. (Mean ± SD; p < 0.05). L prevented the following: HFD-induced increases in systolic blood pressure (SBP) and L-Dopa/dopamine urinary index (HFD vs. C, p < 0.01; HFDL vs. HFD, p < 0.01); lower expression of OCTN-1/2/3 (HFD vs. C, p < 0.01; HFDL vs. HFD, p < 0.05); overexpression of D1DR and Na+/K+-ATPase (HFD vs. C, p < 0.01; HFDL vs. HFD: D1DR p < 0.01; Na+/K+-ATPase p < 0.05), NF-κB1 and TGF-β1 (HFDL vs. HFD, p < 0.01). L mitigated proximal tubular alterations and interstitial fibrosis (HFDL vs. HFD, p < 0.01). Under chronic HFD intake, early L administration prevented renal dopaminergic system alterations and SBP elevation, and attenuated renal inflammation and interstitial fibrosis, reflecting its nephroprotective effects.
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Cantú et al. (2026) studied High-fat diet induced alterations (n=20). Losartan vs. High-fat diet alone / Control was evaluated on Systolic blood pressure (SBP) and L-Dopa/dopamine urinary index (p=<0.01). Early losartan administration in rats fed a high-fat diet prevented systolic blood pressure elevation and renal dopaminergic system alterations (p < 0.01).
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