Prevalence, causes, and predictors of 30-day readmissions after acute myocardial infarction with ventricular arrhythmias: a cohort study using the 2016-2017 national readmissions database.

Q: What are the key findings of this study?

AMI complicated by ventricular arrhythmias was associated with an 8.7% 30-day readmission rate, primarily driven by noncardiac and cardiac comorbidities such as prolonged length of stay, ESRD, and COPD.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Acute myocardial infarction complicated by ventricular arrhythmias (n=93588). Intervention: Acute myocardial infarction complicated by ventricular arrhythmias. Primary outcome: 30-day all-cause readmission rate.

Q: What does this research mean for the field?

Patients surviving acute myocardial infarction complicated by ventricular arrhythmias experience high 30-day readmission rates driven primarily by noncardiac causes and select cardiac conditions such as heart failure and atrial fibrillation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Adarsh Raja; Muhammad Umer Sohail; Muhammad Ans; Saad Ahmed; Ahsan Feroze; Manaal Ashar; Kehan Ali Rizvi; Muhammad Huzaifa Ahmed Khan; Sara Rahman; Muhammad Umer Hayat; Noor ul Ain; Laraib Kamran²; Fnu Pirih; Muhammad Bilal Liaqat; Laksh Kumar; Sumet Kumar; Aayush Chaulagain

doi:10.1097/ms9.0000000000005534

October 1, 2026

Prevalence, causes, and predictors of 30-day readmissions after acute myocardial infarction with ventricular arrhythmias: a cohort study using the 2016-2017 national readmissions database.

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Key result

AMI with ventricular arrhythmias carries an ~9% 30-day readmission rate, driven primarily by comorbidities.

n=93,588

Why the study?

Patients surviving AMI complicated by ventricular arrhythmias are at high risk of early post-discharge readmissions, which worsen outcomes and increase healthcare costs.

Key Points

To investigate the prevalence, causes, costs, and predictors of 30-day readmissions following hospitalization for acute myocardial infarction complicated by ventricular arrhythmias.
Retrospective cohort analysis using the 2016–2017 U.S. National Readmissions Database.
Included 93 588 index hospitalizations for acute myocardial infarction complicated by ventricular arrhythmias.
Multivariate regression analysis was conducted to identify independent demographic and clinical predictors of 30-day all-cause readmissions.
Among 93 588 index hospitalizations, 8154 (8.71%) experienced a 30-day readmission; in-hospital mortality was 16.43% during index admissions and 5.92% during readmissions.
Independent predictors of readmission included ESRD (OR: 1.52; 95% CI: 1.29–1.78; P < 0.001), COPD (OR: 1.43; 95% CI: 1.31–1.57; P < 0.001), prior CHF (OR: 1.28; 95% CI: 1.17–1.40; P < 0.001), and index stay >4 days (OR: 1.94; 95% CI: 1.78–2.11; P < 0.001).
Mean index hospital charges were $151 722 (95% CI: 146 479–156 966), compared with $64 122 (95% CI: 60 824–67 421) per readmission; higher income quartiles were associated with lower readmission risk.

Study Design

Type

Cohort (n=93,588)

Multicenter

Yes

Structured PICO

P

Population

93,588 adult patients hospitalized for acute myocardial infarction complicated by ventricular arrhythmias in the United States, mean age 65 years, 27% female, assessed for 30-day readmissions.

O

Outcome

30-day all-cause readmission rate following discharge from the index hospitalizationhard clinical

Limitations

Observational, nonrandomized analysis with potential unmeasured confounding.
Lacks data on specific clinical and procedural factors such as vascular access site, post-interventional medications, and stent type.
Readmissions cannot be tracked across different states or calendar years, leading to potential underestimation.
Potential ICD-10-CM coding errors and bias associated with administrative databases.
Lack of information on complete revascularization.
Survivor bias (exclusion of patients who died during the index hospitalization may skew associations for severe complications like cardiogenic shock)
Competing risk bias (higher post-discharge mortality in high-risk patients may lead to underestimation of readmission burden)

Implication

Patients surviving acute myocardial infarction complicated by ventricular arrhythmias experience an 8.7% 30-day readmission rate, largely driven by prolonged hospital length of stay and systemic comorbidities like end-stage renal disease.

Abstract

Background: Patients surviving acute myocardial infarction (AMI) complicated by ventricular arrhythmias (VAs) are at high risk of early post-discharge readmissions due to multiple complications. These readmissions worsen clinical outcomes and add substantial financial strain to the U.S. healthcare system. This study investigates the prevalence, causes, and predictors of 30-day readmissions following hospitalization for AMI complicated by VAs. Methods and Higher income quartiles were associated with lower readmission risk. The mean index charges were $151 722, whereas charges per readmission were $64 122. Conclusions: AMI complicated by VAs is associated with high 30-day readmission rates, driven mainly by noncardiac and select cardiac causes such as heart failure and atrial fibrillation. Enhanced monitoring of high-risk groups may improve outcomes and reduce healthcare costs.

Discussion

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Cite This Study

Raja et al. (2026) conducted a cohort in Acute myocardial infarction complicated by ventricular arrhythmias (n=93,588). Acute myocardial infarction complicated by ventricular arrhythmias was evaluated on 30-day all-cause readmission rate. AMI complicated by ventricular arrhythmias was associated with an 8.7% 30-day readmission rate, primarily driven by noncardiac and cardiac comorbidities such as prolonged length of stay, ESRD, and COPD.

synapsesocial.com/papers/6ad0b8f43983294737c0c56d https://doi.org/10.1097/ms9.0000000000005534

View at Publisher

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Prevalence, causes, and predictors of 30-day readmissions after acute myocardial infarction with ventricular arrhythmias: a cohort study using the 2016-2017 national readmissions database.

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Prevalence, causes, and predictors of 30-day readmissions after acute myocardial infarction with ventricular arrhythmias: a cohort study using the 2016-2017 national readmissions database.

Key Points

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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