Key result
Higher NLR correlates positively with hs-TnI levels in acute heart disease.
Why the study?
Diagnosis of acute heart disease often relies on ECG or troponin measurement, which are not available in all healthcare facilities, prompting investigation of NLR as an accessible marker.
Cross-Sectional (n=52)
No
Effect estimate: r = 0.279
p-value: p=0.045
Neutrophil-to-lymphocyte ratio has a modest but statistically significant positive correlation with high-sensitivity troponin I levels, suggesting it may serve as an accessible supplementary inflammatory marker for acute heart disease.
NLR may complement hs-TnI assessment in acute heart disease; leaves open its incremental prognostic value pending prospective validation.
Background: Acute heart disease is among the ten most common non-communicable diseases in Indonesia. Diagnosis of acute heart disease is commonly confirmed using electrocardiography (ECG) or troponin measurement; however, these diagnostic tools are not available in all healthcare facilities. The Neutrophil-to-Lymphocyte Ratio (NLR) is a readily accessible laboratory parameter that can be assessed in patients presenting with chest pain. Purpose: This study aimed to determine the relationship between NLR and High-Sensitivity Troponin I (hs-TnI) levels in patients with acute heart disease who need rapid treatment. Method: This descriptive quantitative study used secondary data obtained from Husada Utama Hospital, Surabaya, covering the period from January 2023 to March 2024. A total of 52 patient records that met the inclusion criteria were analyzed. Statistical analysis was performed using the Spearman correlation test. Result: The findings of this study demonstrated a positive correlation between NLR and hs-TnI levels in patients with acute heart disease at RSUD Husada Utama Surabaya, indicating that an increase in troponin I levels was accompanied by an increase in NLR levels. The majority of patients with acute heart disease are 16 men with a range of ages 46 - 55 years. Data analysis using the Spearman test obtained a correlation coefficient of 0.279, indicating the level of strength of the relationship between variables and a significance value of 0.045 <0.05. Conclusion: There is a significant correlation between NLR and hs-TnI levels in acute heart disease at Husada Utama Hospital, Surabaya.
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Rahayu et al. (2026) conducted a cross-sectional in Acute heart disease (n=52). Neutrophil-to-Lymphocyte Ratio (NLR) was evaluated on Correlation between NLR and hs-TnI levels (r = 0.279, p=0.045). Neutrophil-to-Lymphocyte Ratio (NLR) showed a significant positive correlation with High-Sensitivity Troponin I (hs-TnI) levels in patients with acute heart disease (r = 0.279, p = 0.045).
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