Ревматик Этиологияли Митрал Қопқоқ Нуқсони Мавжуд Беморларда Сурункали Юрак Етишмовчилигини Бўлмачалар Фибрилляцияси Фонида Кечиши

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Chronic heart failure due to rheumatic mitral valve disease (n=90). Intervention: Surgical treatment of mitral valve disease vs. Non-operated (conserved rheumatic mitral valve disease). Primary outcome: Incidence/prevalence of atrial fibrillation (p=<0.001).

Q: What does this research mean for the field?

In patients with chronic heart failure due to rheumatic mitral valve disease, surgical treatment is associated with a higher prevalence of atrial fibrillation (75.6% vs 33.3%) despite improved hemodynamics. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the clinical and hemodynamic parameters of chronic heart failure in patients with rheumatic mitral valve disease in the presence of atrial fibrillation.

Ёқубжонов Абдуллох Орибжон ўғли; Абдуллаев Тимур Атаназарович; Kh.A. Gulomov

doi:10.64156/mju.9614

January 1, 2026Medicinskij žurnal UzbekistanaOpen Access

Ревматик Этиологияли Митрал Қопқоқ Нуқсони Мавжуд Беморларда Сурункали Юрак Етишмовчилигини Бўлмачалар Фибрилляцияси Фонида Кечиши

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Key result

Mitral surgery linked to ~42 percentage points higher AF prevalence in rheumatic heart failure.

P<0.001
n=90

Why the study?

Chronic heart failure clinical and hemodynamic parameters in patients with rheumatic mitral valve disease complicated by atrial fibrillation require evaluation.

Does atrial fibrillation worsen clinical and hemodynamic parameters of chronic heart failure in patients with rheumatic mitral valve disease?

Key Points

To evaluate the clinical and hemodynamic parameters of chronic heart failure in patients with rheumatic mitral valve disease in the presence of atrial fibrillation.
Enrolled 90 patients with chronic heart failure due to rheumatic mitral valve disease (mean age 58±2.97 years; 68.9% female).
Divided participants into surgically operated within the last 5 years (Group I, n=45) and non-operated (Group II, n=45) cohorts, further stratified by the presence of atrial fibrillation.
Evaluated intracardiac hemodynamics, morphological, and functional parameters using transthoracic echocardiography and electrocardiography.
Atrial fibrillation incidence was significantly higher in the operated group at 75.6% compared to 33.3% in the non-operated group (p<0.001).
Patients with atrial fibrillation in both groups exhibited significant left atrial enlargement (Group I p=0.05; Group II p=0.01), higher mitral valve pressure gradients (Group I p=0.04; Group II p=0.05), and elevated systolic pulmonary artery pressure (Group I p=0.04; Group II p=0.002).
Tricuspid regurgitation grade was higher (Group I p=0.02; Group II p=0.001), left ventricular ejection fraction was lower (Group I p=0.02; Group II p=0.05) in atrial fibrillation, and right ventricular pressure was significantly increased in non-operated patients with the arrhythmia (p=0.01).

Study Design

Type

Cross-Sectional (n=90)

Multicenter

No

Structured PICO

Does atrial fibrillation worsen clinical and hemodynamic parameters of chronic heart failure in patients with rheumatic mitral valve disease?

P

Population

90 adults aged 33 to 79 years with chronic heart failure due to rheumatic mitral valve disease were evaluated to compare atrial fibrillation prevalence and hemodynamics between surgically treated and non-operated patients.

E

Exposure

Presence of atrial fibrillation (AF) in patients with rheumatic mitral valve disease and CHF

C

Comparator

Presence of sinus rhythm in patients with rheumatic mitral valve disease and CHF

O

Outcome

Clinical and intracardiac hemodynamic parameters assessed via 12-lead ECG and Echocardiography (including left atrial diameter, mitral valve pressure gradient, tricuspid regurgitation grade, pulmonary artery systolic pressure, left ventricular dimensions, and ejection fraction)surrogate

Main Result

Absolute Event Rate: 75.6% vs 33.3%

p-value: p=<0.001

In patients with rheumatic mitral valve disease and heart failure, the presence of atrial fibrillation is associated with significantly worse intracardiac hemodynamics, including marked left atrial dilation and pulmonary hypertension.

Limitations

Small sample size
Single-center observational design
Potential selection bias, as patients with more severe disease and atrial fibrillation may have been more frequently referred for surgery

Implication

AF persists post-surgery in rheumatic mitral HF despite hemodynamic gains; leaves open whether operative factors drive arrhythmia in cross-sectional data.

Abstract

РЕВМАТИК ЭТИОЛОГИЯЛИ МИТРАЛ ҚОПҚОҚ НУҚСОНИ МАВЖУД БЕМОРЛАРДА СУРУНКАЛИ ЮРАК ЕТИШМОВЧИЛИГИНИ БЎЛМАЧАЛАР ФИБРИЛЛЯЦИЯСИ ФОНИДА КЕЧИШИ - научно-практическая статья медицинского журнала Узбекистана о достижениях в здравоохранении, эпидемиологии, санитарии и фармацевтике, а также о пропаганде ЗОЖ.

Discussion

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Cite This Study

ўғли et al. (2026) conducted a cross-sectional in Chronic heart failure due to rheumatic mitral valve disease (n=90). Surgical treatment of mitral valve disease vs. Non-operated (conserved rheumatic mitral valve disease) was evaluated on Incidence/prevalence of atrial fibrillation (p=<0.001).

synapsesocial.com/papers/6ad0fc2515427f6a8403ff4d https://doi.org/10.64156/mju.9614

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Ревматик Этиологияли Митрал Қопқоқ Нуқсони Мавжуд Беморларда Сурункали Юрак Етишмовчилигини Бўлмачалар Фибрилляцияси Фонида Кечиши

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Ревматик Этиологияли Митрал Қопқоқ Нуқсони Мавжуд Беморларда Сурункали Юрак Етишмовчилигини Бўлмачалар Фибрилляцияси Фонида Кечиши

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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