Key result
Takayasu arteritis with pulmonary involvement is linked to reduced small pulmonary arterial volumes vs controls.
Why the study?
Pulmonary artery involvement in Takayasu arteritis is often diagnosed late and lacks quantitative imaging biomarkers for early detection and disease monitoring.
Does CTPA-based automated quantification identify reduced pulmonary arterial volumes in patients with Takayasu arteritis and pulmonary artery involvement compared with healthy controls?
Case-Control (n=137)
Assessors blinded to clinical data
No
Does CTPA-based automated quantification identify reduced pulmonary arterial volumes in patients with Takayasu arteritis and pulmonary artery involvement compared with healthy controls?
Absolute Event Rate: 59.5% vs 63.7%
p-value: p=0.028
Automated CTPA quantification demonstrates significant volume loss in mid-sized pulmonary arteries (1.6-3.2 mm) in patients with Takayasu arteritis, providing a potential objective imaging biomarker for early detection of pulmonary artery involvement.
Supports CTPA volume quantification for detecting pulmonary involvement in Takayasu arteritis; hypothesis-generating for biomarker validation.
Background: Pulmonary artery involvement (PAI) in Takayasu arteritis (TA) is often diagnosed late and may lead to pulmonary hypertension (PH). Quantitative imaging biomarkers that could aid early detection are currently lacking. This study aimed to quantify pulmonary arterial volumes (PAVs) in TA-PAI using computed tomography pulmonary angiography (CTPA) and to compare imaging features between PAI patients and age-/sex-matched controls, as well as between PAI subgroups with and without PH. Methods: or Fisher's exact test, with Bonferroni correction (P<0.05). Results: . 4%; P=0.007), but cumulative PAVs did not differ significantly. Conclusions: CTPA-based PAV quantification reveals marked volume loss in mid-sized pulmonary arteries in TA-PAI. PAV might be beneficial for detecting TA. However, PAV showed no significant difference between groups according to PH status, despite severe pulmonary arterial structural changes.
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Li et al. (2026) conducted a case-control in Takayasu arteritis with pulmonary artery involvement (n=137). Takayasu arteritis with pulmonary artery involvement vs. Age- and sex-matched controls without pulmonary artery involvement was evaluated on Pulmonary arterial volume for arteries ≤4.0 mm (p=0.028). Patients with Takayasu arteritis and pulmonary artery involvement exhibited significantly reduced pulmonary arterial volumes for arteries ≤4.0 mm (median 59.5 mL vs mean 63.7 mL, P=0.028) compared with matched controls.
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