Key result
Recurrent perimyocarditis unmasks cardiomyopathy with progressive late gadolinium enhancement and biventricular dysfunction.
Why the study?
Pathogenic variants in cardiomyopathy genes are increasingly identified in patients with recurrent myocarditis, reframing some cases as gene–environment interactions.
Case Report (n=1)
Recurrent viral perimyocarditis can act as an environmental trigger unmasking underlying genetic cardiomyopathies, such as Filamin C-related cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Recurrent perimyocarditis may unmask genetic cardiomyopathy; leaves open whether Filamin C screening should be pursued.
Pathogenic variants in cardiomyopathy genes are increasingly identified in patients with recurrent myocarditis, reframing a subset of these cases as gene–environment interactions. We report a 20-year-old male with three episodes of viral-associated perimyocarditis over two years. Serial cardiac magnetic resonance demonstrated progressive extension of late gadolinium enhancement with declining biventricular function. Endomyocardial biopsy confirmed virus-negative lymphocytic myocarditis with Z-disc pathology.
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Bertelli et al. (2026) conducted a case report in Recurrent viral perimyocarditis and Filamin C-related cardiomyopathy (n=1). Recurrent viral perimyocarditis was evaluated. Recurrent viral-associated perimyocarditis in a 20-year-old male unmasked a cardiomyopathy, leading to progressive late gadolinium enhancement and declining biventricular function.
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