Key result
Childhood adversity is linked to blunted stress cardiovascular reactivity, compounded by high autonomic genetic risk.
Why the study?
Does autonomic nervous system multilocus genetic variation moderate the association between childhood adversity and stress cardiovascular reactivity in adolescents?
Cross-Sectional (n=614)
No
Does autonomic nervous system multilocus genetic variation moderate the association between childhood adversity and stress cardiovascular reactivity in adolescents?
This study reveals the gene-environment interaction mechanism underlying stress cardiovascular dysregulation in adolescents, highlighting multilocus genetic variation as a key moderator of physiological resilience.
Gene-environment interactions may shape adolescent cardiovascular reactivity; supports differential susceptibility model but remains hypothesis-generating and should not yet change practice.
摘要： 童年期逆境与自主神经系统支配下的应激心血管反应功能失调密切相关, 但目前仍缺乏研究从环境和基因交互的视角探究其形成机制。研究在两个独立样本(样本1包含256名青少年, Mage = 12.95 ± 0.79岁; 样本2包含358名青少年, Mage = 12.98 ± 0.74岁)
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Ye Huang (2026) conducted a cross-sectional in Childhood adversity and stress cardiovascular dysregulation (n=614). Childhood adversity vs. Low childhood adversity was evaluated on Cardiovascular reactivity to stress (Heart rate, systolic and diastolic blood pressure). Childhood adversity was negatively associated with stress cardiovascular reactivity, with higher genetic risk scores exacerbating blunted reactivity under high childhood adversity.
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