Key result
Global longitudinal strain was significantly lower in patients with significant coronary artery disease (mean -18.46) compared to those with non-significant disease (mean -22.34), and decreased incrementally with multi-vessel involvement.
Why the study?
Significant coronary artery stenosis may cause persistently impaired longitudinal left ventricle function at rest, and the diagnostic accuracy of LV global longitudinal strain by 2D speckle-tracking echocardiography in predicting CAD severity in acute coronary syndrome needed evaluation.
Does global longitudinal strain measured by 2D speckle tracking echocardiography predict the severity of coronary artery disease in patients with acute coronary syndrome?
Cross-Sectional (n=100)
No
Does global longitudinal strain measured by 2D speckle tracking echocardiography predict the severity of coronary artery disease in patients with acute coronary syndrome?
Absolute Event Rate: -18.46% vs -22.34%
p-value: p=<0.001
Measurement of global longitudinal strain using 2D speckle-tracking echocardiography provides a sensitive and accurate non-invasive method to predict the severity of coronary artery disease in patients with acute coronary syndrome.
Background:Significant coronary artery stenosis might cause persistently impaired longitudinal left ventricle functionat rest. LV global longitudinal strain (GLS) can be accurately assessed by 2D speckle-tracking strain echocardiography (2D-STE) in correlation with coronary angiogram (CAG).Objective:We aimed to evaluate the diagnostic accuracy of LV global longitudinalstrain obtained by 2D-STE in the prediction of the severity of coronary artery disease (CAD) in acute coronary syndrome. Methods:100 patients with the acute coronary syndrome were included. They underwent transthoracic echocardiography (TTE) to measure GLS and they also underwent coronary angiography (CA). Images were obtained in the apical long-axis, four-chamber, and two chamber views. The regional longitudinal systolic strain was measured in 17 myocardial segments and averaged to provide global longitudinal strain (GLS). This GLS was co-related to the severity of coronary artery disease. Results: There was a significant decrease in GLS in patients with the significant coronary artery disease as compared to a patient with non-significant coronary artery disease. The GLS in patient with non-significant coronary artery disease was -22.34±0.32. The value of GLS in single-vessel CAD, double vessel CADand triple vesselCAD being -18.88±1.07, -17.33±0.8, -15.33±0.45respectively. The GLS cut off valve was found to be -18.46+3.18 (p=<0.001).The sensitivity of GLS in SVD, DVD, TVD was 96.88%, 85% and 88.46% respectively and specificity was 81.29%,70.1% and 69.81% respectively. There was a significant positive correlation between GLS and the severity of coronary artery disease which was seen as incremental significant decrease in GLS with an increasing number of coronary vessels involved.Conclusion:Measurement of global longitudinal strain using 2D speckle tracking echocardiography is a sensitive andaccurate tool in theprediction of severity CADin acute coronary syndromes.
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Anoop Motiram Bardeskar (2026) conducted a cross-sectional in Acute Coronary Syndrome (n=100). Global longitudinal strain (GLS) assessment by 2D-STE vs. Non-significant coronary artery disease (stenosis <50%) was evaluated on Mean Global Longitudinal Strain (GLS) in significant vs. non-significant coronary artery disease (p=<0.001). Global longitudinal strain was significantly lower in patients with significant coronary artery disease (mean -18.46) compared to those with non-significant disease (mean -22.34), and decreased incrementally with multi-vessel involvement.
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